Beckman Coulter Inc. is laying off 141 employees in Chatsworth, according to documents filed with the state.

The Brea biomedical instrument manufacturer will be closing its Chatsworth facility and relocating operations to an existing facility in Miami. The Chatsworth facility will permanently close Dec. 31.

In the notice filed with the state’s Employment Development Department, the company said it will be working to retain selected employees in other company operations wherever possible. A majority of employees affected are listed as technicians and engineers, according to documents. The company added that the list of impacted individuals is expected to change as employees are relocated and reassigned over the next few months.

Beckman Coulter is a subsidiary of Danaher Corp., manufacturer of diagnostic and industrial technology products.

The company could not be reached for comment before press time.

Shares of Danaher (DHR) on Wednesday closed down 23 cents or less than 1 percent at $86.96 on the New York Stock Exchange.